Fig. 1
bTVBT2 inside microglia in the human retina. A representation of the human retina showing the region used in this study (inferior-nasal, green field) is seen in A. The molecular structure of bTVBT2 is shown in B. Confocal image of the orthogonal view of a bTVBT2-positive signal inside an Iba1-positive microglia is shown in C. Graph in D shows a higher number of bTVBT2-positive microglia density in the retina of Aβhigh cases compared to Aβlow cases. Data was analyzed using the Mann–Whitney U test and is presented as a median with a 95% confidence interval. Significant difference at * = p < 0.05. A case with low amyloid-beta load (Aβlow) showing no bTVBT2 inside retinal microglia is seen in E, and a case with high amyloid-beta load (Aβhigh) with bTVBT2-positive deposits inside retinal microglia (white arrows) is shown in F. Scale bar in B represent 20 µm and scale bar in D and E represent 20 µm. Scatter plot in G shows the correlation between bTVBT2-positive microglia density in the retina and NFT staging in the brain. Data was analyzed using Spearman’s rank correlation coefficient