White matter integrity is associated with cognition and amyloid burden in older adult Koreans along the Alzheimer’s disease continuum

Hirschfeld, Lauren R.; Deardorff, Rachael; Chumin, Evgeny J.; Wu, Yu-Chien; McDonald, Brenna C.; Cao, Sha; Risacher, Shannon L.; Yi, Dahyun; Byun, Min Soo; Lee, Jun-Young; Kim, Yu Kyeong; Kang, Koung Mi; Sohn, Chul-Ho; Nho, Kwangsik; Saykin, Andrew J.; Lee, Dong Young

doi:10.1186/s13195-023-01369-5

Alzheimer's Research & Therapy

Table 3 Partial correlations of DTI values from the left (a) and right (b) CBH with cognitive exams. Significance is indicated with an asterisk (*) and is determined at the Bonferroni-adjusted alpha level of 0.0015. All partial correlations in this table are controlled for age, sex, and years of education at time of scan

From: White matter integrity is associated with cognition and amyloid burden in older adult Koreans along the Alzheimer’s disease continuum

Cognitive measure	FA		RD		AxD		MD
Cognitive measure	r	p	r	p	r	p	r	p
a. Association of imaging measures with cognitive exams in the left cingulum bundle of the hippocampus
Digit Span Forward	0.052	0.249	− 0.115	0.010	− 0.194	< 0.001^*	− 0.129	0.004
Digit Span Backward	0.196	< 0.001^*	− 0.172	< 0.001^*	− 0.131	0.003	− 0.146	0.001^*
TMTA	− 0.246	< 0.001^*	0.264	< 0.001^*	0.188	< 0.001^*	0.254	< 0.001^*
TMTB	− 0.195	< 0.001^*	0.226	< 0.001^*	0.175	< 0.001^*	0.217	< 0.001^*
Geriatric Depression Scale	− 0.445	< 0.001^*	0.486	< 0.001^*	0.363	< 0.001^*	0.485	< 0.001^*
MMSE-KC	0.395	< 0.001^*	− 0.462	< 0.001^*	− 0.350	< 0.001^*	− 0.464	< 0.001^*
CDR Sum of Boxes	− 0.445	< 0.001^*	0.484	< 0.001^*	0.345	< 0.001^*	0.478	< 0.001^*
SMCQ Total Memory Decline	− 0.097	0.030	0.166	< 0.001^*	0.152	< 0.001^*	0.176	< 0.001^*
Word List Recall (Immediate) Total Score	0.230	< 0.001^*	− 0.282	< 0.001^*	− 0.270	< 0.001^*	− 0.293	< 0.001^*
Word List Recall (Delay) Total Score	0.405	< 0.001^*	− 0.457	< 0.001^*	− 0.353	< 0.001^*	− 0.461	< 0.001^*
Logical Memory (Immediate) Total Score	0.356	< 0.001^*	− 0.385	< 0.001^*	− 0.287	< 0.001^*	− 0.382	< 0.001^*
Logical Memory (Delay) Total Score	0.321	< 0.001^*	− 0.336	< 0.001^*	− 0.240	< 0.001^*	− 0.327	< 0.001^*
b. Association of imaging measures with cognitive exams in the right cingulum bundle of the hippocampus
Digit Span Forward	0.041	0.358	− 0.098	0.028	− 0.136	0.002	− 0.098	0.029
Digit Span Backward	0.169	< 0.001^*	− 0.196	< 0.001^*	− 0.174	< 0.001^*	− 0.185	< 0.001^*
TMTA	− 0.291	< 0.001^*	0.382	< 0.001^*	0.305	< 0.001^*	0.386	< 0.001^*
TMTB	− 0.188	< 0.001^*	0.252	< 0.001^*	0.271	< 0.001^*	0.261	< 0.001^*
Geriatric Depression Scale	− 0.327	< 0.001^*	0.520	< 0.001^*	0.488	< 0.001^*	0.543	< 0.001^*
MMSE-KC	0.332	< 0.001^*	− 0.501	< 0.001^*	− 0.461	< 0.001^*	− 0.517	< 0.001^*
CDR Sum of Boxes	− 0.334	< 0.001^*	0.516	< 0.001^*	0.470	< 0.001^*	0.538	< 0.001^*
SMCQ Total Memory Decline	− 0.070	0.117	0.187	< 0.001^*	0.200	< 0.001^*	0.201	< 0.001*
Word List Recall (Immediate) Total Score	0.206	< 0.001^*	− 0.288	< 0.001^*	− 0.288	< 0.001^*	− 0.292	< 0.001^*
Word List Recall (Delay) Total Score	0.313	< 0.001^*	− 0.473	< 0.001^*	− 0.441	< 0.001^*	− 0.485	< 0.001^*
Logical Memory (Immediate) Total Score	0.285	< 0.001^*	− 0.383	< 0.001^*	− 0.361	< 0.001^*	− 0.392	< 0.001^*
Logical Memory (Delay) Total Score	0.278	< 0.001^*	− 0.363	< 0.001^*	− 0.325	< 0.001^*	− 0.364	< 0.001^*

TMTA Trail Making Test A, TMTB Trail Making Test B, MMSE-KC Mini-Mental State Exam in the Korean Version of the CERAD, CDR Clinical Dementia Rating Scale, SMCQ Subjective Memory Complaints Questionnaire

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ISSN: 1758-9193

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