Table 2 Overall ANCOVA results and post hoc between-group differences of WM integrity in the left and right cingulum bundle of the hippocampus (CBH) as measured through the 4 commonly acquired diffusion tensor imaging (DTI) indices: fractional anisotropy (FA), radial diffusivity (RD), axial diffusivity (AxD), and mean diffusivity (MD). When controlling for age and sex, all groups had significantly different average DTI values in each hemisphere
Left cingulum bundle of the hippocampus | Right cingulum bundle of the hippocampus | |||||||
|---|---|---|---|---|---|---|---|---|
F(2,500) | p | \({\eta }_{p}^{2}\) | Post hoc | F(2,500) | p | \({\eta }_{p}^{2}\) | Post hoc | |
FA | 61.562 | < 0.001 | 0.198 | CN and MCI: p = 0.002 CN and AD: p < 0.001 MCI and AD: p < 0.001 | 31.359 | < 0.001 | 0.111 | CN and MCI: p = 0.015 CN and AD: p < 0.001 MCI and AD: p < 0.001 |
RD | 80.705 | < 0.001 | 0.244 | CN and MCI: p < 0.001 CN and AD: p < 0.001 MCI and AD: p < 0.001 | 96.300 | < 0.001 | 0.278 | CN and MCI: p < 0.001 CN and AD: p < 0.001 MCI and AD: p < 0.001 |
AxD | 39.835 | < 0.001 | 0.137 | CN and MCI: p < 0.001 CN and AD: p < 0.001 MCI and AD: p < 0.001 | 82.884 | < 0.001 | 0.249 | CN and MCI: p < 0.001 CN and AD: p < 0.001 MCI and AD: p < 0.001 |
MD | 81.016 | < 0.001 | 0.245 | CN and MCI: p < 0.001 CN and AD: p < 0.001 MCI and AD: p < 0.001 | 110.980 | < 0.001 | 0.307 | CN and MCI: p < 0.001 CN and AD: p < 0.001 MCI and AD: p < 0.001 |