Fig. 2
From: A single-domain antibody detects and neutralises toxic Aβ42 oligomers in the Alzheimer’s disease CSF
DesAb-O detects synthetic Aβ42 oligomers interacting with neuronal cells. A Representative STED microscopy images of SH-SY5Y cells treated with the indicated Aβ42 species at 3.0 μM (monomer equivalents) for 1 h. Red and green fluorescence indicates respectively the cell membranes and the Aβ42 species, detected with the indicated Abs. B The histograms represent the results of a semi-quantitative analysis of the green fluorescent signal. Experimental errors are S.E.M. (n = 3). Samples were analysed by Student t test relative to untreated cells (**P < 0.01, and ***P < 0.001), or to cells treated with the same Aβ42 species and detected with DesAb-O (§P < 0.05, §§P < 0.01, §§§P < 0.001). 200–250 cells were analysed per condition