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Table 5 Cognitive decline in subgroups of simvastatin users compared to atorvastatin users

From: Statins and cognitive decline in patients with Alzheimer’s and mixed dementia: a longitudinal registry-based cohort study

Simvastatin users (ref. atorvastatin users)

 

Men

Women

Younger

Older

 

Coeff.

95% CI

p-value

Coeff.

95% CI

p-value

Coeff.

95% CI

p-value

Coeff.

95% CI

p-value

Average

-0.03

-0.09; 0.02

0.200

-0.03

-0.08; 0.02

0.246

-0.05

-0.11; 0.01

0.123

-0.02

-0.06; 0.02

0.369

Per year

0.49

-0.07; 1.04

0.086

0.23

-0.09; 0.56

0.153

0.28

0.03; 0.54

0.029

0.60

-0.43; 1.63

0.251

After 3 years

1.42

-0.22; 3.07

0.089

0.67

-0.28; 1.63

0.168

0.80

0.05; 1.55

0.037

1.79

-1.27; 4.85

0.252

  1. Linear mixed-effects regression model with inverse probability weighting, adjusted model for selected demographic characteristics, comorbidities and comedication (details in methods). Analysis stratified on sex and mean age (79.5 years) at index date. Coefficient for the point-wise difference in MMSE points over time between simvastatin and atorvastatin users, 95 % CI and two-sided p-values are reported. Average refers to the average difference in MMSE points between comparison groups at any time point