Fig. 6

Excitatory and inhibitory mean firing rates as a function of the A\(\beta\) inhibitory scaling \(s^I_{A\beta }\), with all the other parameters of the model at the (averaged) fitted optimum values. For the purpose of clarity, the horizontal axis for the scaling has been taken as absolute values, to illustrate the behavior with increasing A\(\beta\) loads. The vertical axis shows the firing rates of both excitatory and inhibitory populations. It can be clearly seen that the net effect of the burden is to increase the overall region firing rate, measured at the excitatory population. For the sake of clarity, the inhibitory firing rate has been vertically inverted (negated) to show their decreased effect on the excitatory population, thus confirming previous findings [15]. The vertical discontinuous line shows the optimum found for \(s^I_{A\beta }\)