Fig. 4

Parameter values found after the optimization stage for HC, MCI and AD subjects. Observe that all \(b^{(E,I)}_{(A\beta ,\tau )}\), the excitatory/inhibitory A\(\beta\) and tau bias parameters, have negligible values, while the scaling parameters \(s^{(E,I)}_{(A\beta ,\tau )}\) present non-null values. Of note, the p-values between the different scaling parameters across the cohorts are different in a moderately significant way (\(p<0.03\)), remarkably between HC and AD, but usually not between MCI and AD. In these plots, boxes extend from the lower to upper quartile values of the data, adding an orange line at the median. Also, whiskers are used to show the range of the data, extending from the box