Fig. 11
From: Neuronal transcriptome, tau and synapse loss in Alzheimer’s knock-in mice require prion protein
Pathways expression-normalized in DKI neurons by loss of PrPC function. Functional enrichment analysis of AD-associated DEGs (DKI versus WT) corrected by Prnp deletion in pooled excitatory and inhibitory neuron samples. A Leading terms are color highlighted with corresponding p-values and total gene association count of each function group is graphed. B Gene set enrichment analysis against GO Molecular Function terms, KEGG and REAC Pathways, organized into functional network groups (nodes) based on shared gene associations (edges). C Functionally enriched PPI networks (encircled) with genes having stronger associations connected by thicker lines and genes with lesser or unknown associations not shown