Table 3 Linear mixed effect models showing EQ-5D utility and VAS trajectories

Clinical stage

 < 0.001

 < 0.001

 SCD

Reference

Reference

 MCI

 − 0.015 (0.004)^a

 − 1.695 (0.274)^a

 Mild

 − 0.077 (0.015)^a

 − 4.401 (0.676)^a

 Moderate

 − 0.053 (0.021)^a

 − 4.999 (0.8)^a

 Severe

0.043 (0.158)

 − 15.386 (3.142)^a

 Time (year)

 − 0.007 (0.001)

 − 0.518 (0.062)

Clinical stage × time interaction

 < 0.05

 SCD × time

Reference

 MCI × time

0 (0.002)

 Mild × time

0.005 (0.005)

 Moderate × time

 − 0.015 (0.006)^a

 Severe × time

 − 0.09 (0.04)^a