Table 2 Associations of polygenic score for general cognition with baseline cognitive function measurements

Word recall

 Base model

0.545 (0.033)

< 0.0001

0.026

0.224 (0.063)

0.0004

0.009

 Base model + age and sex

0.591 (0.030)

< 0.0001

0.216

0.220 (0.060)

0.0002

0.120

 Base model + age, sex, and APOE

0.588 (0.030)

< 0.0001

0.219

0.221 (0.060)

0.0002

0.121

 Full model

0.412 (0.029)

< 0.0001

0.279

0.137 (0.057)

0.02

0.207

Mental status

 Base model

0.513 (0.024)

< 0.0001

0.055

0.317 (0.059)

< 0.0001

0.022

 Base model + age and sex

0.526 (0.023)

< 0.0001

0.110

0.320 (0.057)

< 0.0001

0.105

 Base model + age, sex, and APOE

0.525 (0.023)

< 0.0001

0.112

0.319 (0.057)

< 0.0001

0.108

 Full model

0.385 (0.023)

< 0.0001

0.195

0.211 (0.051)

< 0.0001

0.278

Total cognitive function

 Base model

1.031 (0.053)

< 0.0001

0.047

0.523 (0.112)

< 0.0001

0.018

 Base model + age and sex

1.097 (0.048)

< 0.0001

0.207

0.532 (0.104)

< 0.0001

0.146

 Base model + age, sex, and APOE

1.093 (0.048)

< 0.0001

0.211

0.531 (0.104)

< 0.0001

0.149

 Full model

0.787 (0.046)

< 0.0001

0.305

0.339 (0.094)

0.0003

0.309