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Table 3 Effect of LDL-c levels on Aβ uptake and HV

From: Distinct effects of cholesterol profile components on amyloid and vascular burdens

  

Unstandardized β (SE)

Standardized β (SE)

p

Indirect

LDL-c → Aβ → HV

-0.253 (0.092)

-0.018 (0.006)

0.006

Component

LDL-c → Aβ

0.104 (0.035)

0.078 (0.026)

0.003

 

Aβ → HV

-2.436 (0.317)

-0.226 (0.029)

 < 0.001

Direct

LDL-c → HV

-0.759 (0.370)

-0.053 (0.026)

0.040

Total

LDL-c → HV

-1.012 (0.379)

-0.071 (0.026)

0.007

  1. Path analyses were performed using LDL-c as a predictor, Aβ uptake as a mediator, and hippocampal volume as an outcome, after controlling for age, sex, BMI, APOE4 genotype, hypertension, diabetes, lipid-lowering medication, dementia medication, and intracranial volume. The standardized β was calculated to compare the strength of the effect of each independent variable on each dependent variable
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Alzheimer's Research & Therapy

ISSN: 1758-9193