Skip to main content

Table 2 Association of cholesterol levels with Aβ uptake, WMH volume, and HV

From: Distinct effects of cholesterol profile components on amyloid and vascular burdens

 

Aβ uptake

WMH volume

HV

 

β

(95% CI)a

p

β

(95% CI)

p

β

(95% CI)

p

Unstandardized

LDL-c

0.085

(0.018, 0.153)

0.013

0.003

(-0.002, 0.009)

0.204

-0.942

(-1.693, -0.192)

0.014

HDL-c

0.043

(-0.100, 0.187)

0.552

-0.012

(-0.024, -0.001)

0.032

0.468

(-1.128, 2.064)

0.565

Triglyceride

-0.021

(-0.062, 0.020)

0.308

0.001

(-0.002, 0.004)

0.474

-0.037

(-0.501, 0.426)

0.875

Standardizedb

 LDL-c

0.064

(0.014, 0.115)

0.013

0.040

(-0.022, 0.103)

0.204

-0.065

(-0.117, -0.013)

0.014

 HDL-c

0.016

(-0.036, 0.067)

0.552

-0.069

(-0.133, -0.006)

0.032

0.015

(-0.037, 0.068)

0.565

 Triglyceride

-0.025

(-0.074, 0.023)

0.308

0.022

(-0.039, 0.083)

0.474

-0.004

(-0.055, 0.047)

0.875

  1. Abbreviations: Aβ Amyloid-β, BMI Body mass index, CI Confidence interval, HDL-c High-density lipoprotein cholesterol, HV Hippocampal volume, LDL-c Low-density lipoprotein cholesterol, WMH White matter hyperintensity
  2. aβ was obtained by general linear regression analyses with each cholesterol (LDL-c, HDL-c, and triglycerides) as a predictor and quantified dcCL scale as an outcome, after controlling for age, sex, BMI, APOE4 genotype, hypertension, diabetes, lipid-lowering medication, and dementia medication
  3. bStandardized β was calculated to compare the strength of the effect of each independent variable on each dependent variable
Back to article page

Alzheimer's Research & Therapy

ISSN: 1758-9193