Table 2 Longitudinal association of subjective cognitive complaints and APOE ε4 genotype with risk of all-cause dementia over 17-year follow-up (ESTHER cohort)

Subjective cognitive complaints

 No

81 (17.9)

1607 (29.4)

Reference

Reference

 Occasional

270 (59.9)

3231 (59.0)

1.33 (1.02–1.74), 0.0373

1.32 (1.00–1.76), 0.0546

 Persistent

100 (22.2)

637 (11.6)

2.18 (1.58–3.02), < 0.0001

2.15 (1.52–3.06), < 0.0001

APOE ε4

 APOE ε4 − ^d

254 (56.3)

3894 (71.1)

Reference

Reference

 APOE ε4 + ^e

170 (37.7)

1296 (23.7)

2.21 (1.78–2.74), < 0.0001

2.06 (1.65–2.57), < 0.0001

Subjective cognitive complaints and APOEε4

 No and APOE ε4 − 

46 (10.2)

1136 (20.7)

Reference

Reference

 No and APOE ε4 + 

32 (7.1)

388 (7.1)

2.34 (1.43–3.83), 0.0007

2.46 (1.49–4.08), 0.0005

 Occasional and APOE ε4 − 

158 (35.0)

2290 (41.8)

1.41 (0.99–2.00), 0.0598

1.49 (1.03–2.14), 0.0340

 Occasional and APOE ε4 + 

93 (20.6)

760 (13.9)

2.71 (1.85–3.99), < 0.0001

2.69 (1.80–4.01), < 0.0001

 Persistent and APOE ε4 − 

50 (11.8)

468 (8.5)

1.90 (1.22–2.95), 0.0043

2.14 (1.36–3.37), 0.0010

 Persistent and APOE ε4 + 

45 (11.1)

148 (2.7)

5.60 (3.47–9.03), < 0.0001

5.35 (3.25–8.81), < 0.0001