Fig. 1

CSF biomarker levels in different study groups in the Aβ-positive cohort. Comparison of different groups of ABCA7 mutation carriers or non-carriers, in the Aβ-positive cohort, using boxplots, depicting median and IQR, for the untransformed biomarkers: Aβ_1–42 (A), Aβ_1–40 (B), Aβ ratio (C), YKL-40 (D), sAPPα (E), sAPPβ (F), T-tau (G), P-tau₁₈₁ (H), and hFABP (I). Linear regression on INT transformed data was performed between different groups with age, sex, and APOE ε4 status as covariates. *P < 0.05, **P < 0.01