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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Blockade of adenosine A2A receptors reverses early spatial memory defects in the APP/PS1 mouse model of Alzheimer’s disease by promoting synaptic plasticity of adult-born granule cells

Fig. 3

Blockade of A2AR Ameliorated Spatial Memory Impairment in APP/PS1 Mice during OLT and Y Maze. A Simplified scheme of the OLT test in mice, n = 14 animals per group. B No significant differences in the time exploring each of two identical objects were observed between the groups. C In the test session, WT mice showed significant preference for the novel location. APP/PS1 mice showed no object location preference, while SCH58261 treatment reversed location preference of APP/PS1 mice. D The summary bar graph illustrates that compared to WT mice, APP/PS1 mice exhibited a lower discrimination index. Notably, treatment with SCH58261 increased the discrimination index in APP/PS1 mice. E Heat map of Y Maze Test, n = 10 animals per group. F-G Y maze assessment found that APP/PS1 mice spent less time in the novel arm (F) and had a significantly lower percentage of spontaneous alternation (G). The SCH58261 treatment reversed this in APP/PS1 mice. Data are presented as the mean ± SEM, ***p < 0.001 by Student’s t-test or one-way ANOVA followed by Sidak’s post-hoc test

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Alzheimer's Research & Therapy

ISSN: 1758-9193