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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Blockade of adenosine A2A receptors reverses early spatial memory defects in the APP/PS1 mouse model of Alzheimer’s disease by promoting synaptic plasticity of adult-born granule cells

Fig. 2

Blockade of A2AR Ameliorated Spatial Memory Impairment in APP/PS1 Mice during Morris Water Maze Testing. A Spatial discrimination of mice was assessed using MWM tests. Mice exhibited progressively reduced escape latencies in searching for the platform during acquisition training. The escape latencies were significantly longer in the APP/PS1 group than in the WT group, while treatment with SCH58261 decreased the escape latency of APP/PS1 mice. B No significant differences in swimming speed were observed between the groups. C Representative swimming paths of mice while searching for the hidden platform in probe trials. D-E Analysis of variance (ANOVA) showed lower percentage of time and distance spent in the target quadrant in APP/PS1 mice compared to WT mice. However, this difference between genotypes was abolished by SCH58261 treatment. Data are presented as the mean ± SEM, n = 6 animals per group, *p < 0.05, **p < 0.01 by repeated-measures ANOVA or one-way ANOVA followed by Sidak's post-hoc test

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Alzheimer's Research & Therapy

ISSN: 1758-9193