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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Evaluation of cerebrospinal fluid levels of synaptic vesicle protein, VAMP-2, across the sporadic Alzheimer’s disease continuum

Fig. 2

CSF profile of synaptic markers in AD. A–C Pairwise correlation of VAMP-2, SNAP-25 and neurogranin (Ng) in controls (blue) and in participants on the AD continuum (orange). Linear regression lines are shown for each group. Shaded areas represent standard error of the regression lines. D–F Violin plots showing mean and standard error (box) CSF levels of VAMP-2, Ng and SNAP-25 in cognitively healthy controls and patients across the AD continuum; (preclinical) Stage 1, (preclinical) Stage 2, prodromal AD (pAD) and AD dementia (dAD). Bars mark comparisons where Bonferonni-adjusted ANCOVA p < 0.05 using log2 transformed levels, and adjusted for age. G–I Receiver operating characteristic (ROC) curves of synaptic proteins at different disease stages: Stage 1 (G), pAD (H), dAD (I)

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Alzheimer's Research & Therapy

ISSN: 1758-9193