Divergent brain regional atrophy and associated fiber disruption in amnestic and non-amnestic MCI

Table 1 Demographics of participants

	Controls (n = 50)	aMCI (n = 56)	naMCI (n = 52)	F/x²	p
Age (years)	65.0 ± 7.0	66.1 ± 8.0	66.1 ± 8.0	0.3	0.726
Education (years)	11.6 ± 3.0	11.5 ± 3.0	10.8 ± 3.5	0.9	0.418
Male/female	21/29	20/36	18/34	0.7	0.707
MMSE	28.1 ± 1.4	27.0 ± 1.8	26.9 ± 1.7	8.9	< 0.001^a,b
Memory
AVLT delay	5.7 ± 2.0	1.2 ± 1.1	4.4 ± 1.7	107.7	< 0.001^a,b,c
AVLT total	30.0 ± 7.0	15.5 ± 4.3	25.5 ± 6.2	85.1	< 0.001^a,b,c
R-O delay	14.9 ± 4.7	8.1 ± 6.3	10.2 ± 5.9	19.6	< 0.001^a,b,c
Visual ability
R-O copy	35.0 ± 1.3	32.7 ± 5.5	28.6 ± 7.1	18.9	< 0.001^a,b,c
CDT	25.0 ± 3.2	22.4 ± 5.2	21.0 ± 6.2	8.3	< 0.001^a,b
Language
CVFT	46.1 ± 8.2	40.7 ± 9.2	39.9 ± 8.7	7.8	< 0.001^a,b
BNT	25.0 ± 2.4	22.1 ± 3.5	21.9 ± 3.9	13.4	< 0.001^a,b
Attention
SDMT	37.5 ± 7.0	31.8 ± 8.3	23.2 ± 6.9	46.4	< 0.001^a,b,c
TMTA	51.3 ± 12.8	58.4 ± 15.8	96.6 ± 38.6	48.6	< 0.001^b,c
Execution
StroopCtime	74.4 ± 14.6	89.9 ± 27.9	94.6 ± 28.6	9.3	< 0.001^a,b
TMTB	139.1 ± 34.8	191.9 ± 66.2	259.5 ± 85.1	42.8	< 0.001^a,b,c

aMCI Amnestic mild cognitive impairment, naMCI Non-amnestic mild cognitive impairment, MMSE Mini Mental Status Examination, AVLT Auditory Verbal Learning Test, R-O Rey-Osterrieth Complex Figure, CDT Clock Drawing Test; CVFT, Category Verbal Fluency Test, BNT Boston Naming Test, SDMT Symbol Digit Modalities Test, TMT Trail Making Test, StroopCtime Time of Stroop Word Color Test C
^aStatistically significant difference between controls and aMCI at p < 0.05
^bStatistically significant difference between controls and naMCI at p < 0.05
^cStatistically significant difference between aMCI and naMCI at p < 0.05

ISSN: 1758-9193