Fig. 2
From: PACAP–Sirtuin3 alleviates cognitive impairment through autophagy in Alzheimer’s disease
mRNA profiling showed that PACAP altered the expression of autophagy-related genes in 3xTg mice. A Volcano plot shows 614 upregulated genes and 643 downregulated genes in PACAP-treated APP/PS1/tau triple-transgenic mice compared with normal saline-treated APP/PS1/tau triple-transgenic mice. B Heat map shows differentially expressed genes in PACAP-treated AD model mice. C KEGG pathway networks show several important autophagy-related pathways. n = 4