Fig. 1
From: PACAP–Sirtuin3 alleviates cognitive impairment through autophagy in Alzheimer’s disease
Behavioral experiments showed that cognitive impairment in 3xTg mice was alleviated by PACAP. A Water maze frequency of platform crossing, compared among WT, 3xTg, and 3xTg + PACAP groups. WT = wild-type mice treated with 0.9% normal saline, 3xTg = APP/PS1/tau triple-transgenic mice treated with 0.9% normal saline, and 3xTg + PACAP = APP/PS1/tau triple-transgenic mice treated with PACAP (0.6 μg per day for 4 weeks). B Total times mice spent in the quadrant where the platform had been located. C Escape from the water maze to the platform within the first 4 days of training. D Movement trajectories of mice on the first 4 days of water maze training. n = 8–9. *p < 0.05, **p < 0.01, ***p < 0.001