Fig. 1
From: Quantitative estimate of cognitive resilience and its medical and genetic associations
CR score calculation and related terms. A CR has two components, reserve and compensation (currently not measured), that along with damage are the result of genetics, aging, and environmental factors. Cognitive function is the outcome of CR minus the impact of brain damage. The strategy for calculating the CR score uses measures of cognitive function from cognitive assessments (four neuropsychological tests and cognitive diagnosis) and the ML-based estimation of damage from consensus ordinal rankings of 17 neuropathologic features of AD and ADRDs. B The hypothetical trajectory of CR score and other related terms across the adult lifespan with damage evidenced by pathological changes starting from age of 65. C An example trajectory of resistant individuals, i.e., those rare individuals who did not develop damage into late life. D Cognitive function trajectories and categorized cognitive status—NCI/MCI/dementia resulting from different scenarios of low vs. high damage, reserve, and compensation