Table 2 Baseline demographic and clinical characteristics

N

88

60

148

Age, years (mean, SD)

70.7 (7.2)^**

66.9 (8.2)

69.2 (7.8)

Sex (male/female)

46/42

31/29

77/71

MMSE (median, IQR)

27 (3)^***

24 (5)

26 (4)

MTA score (median, IQR)

 Left hemisphere

2 (2)

1 (2)

2 (2)

 Right hemisphere

2 (1)

2 (2)

2 (2)

Aβ + (nn, CSF Aβ₄₂/ [¹¹C] PiB-PET)

88/0

57/3

145/3

Phosphorylated tau (n, CSF p-tau +/-)

46/4

33/8

79/12

Total tau (n, CSF t-tau +/-)

44/6

33/8

77/14

Medication use (n/%)

 Anticholinergics

4 (5%)

6 (10%)

10 (7%)

 Antidepressants

9 (10%)

5 (8%)

14 (9%)

 AEDs

1 (1%)

3 (5%)

4 (3%)

 Antipsychotics

1 (1%)

1 (2%)

2 (1%)

 Benzodiazepines

3 (3%)

5 (8%)

8 (5%)