Longitudinal resting-state EEG in amyloid-positive patients along the Alzheimer’s disease continuum: considerations for clinical trials

Table 10 Required sample sizes (per arm) to detect different treatment effects on EEG outcome measures in Aβ + MCI or AD dementia patients, in a hypothetical trial of 1- or 2-year duration, at 80% power

Subjects	Region	Frequency band	Measure	Sample size (50% less deterioration)		Sample size (stabilization)		Sample size (50% improvement)
				1 year	2 years	1 year	2 years	1 year	2 years
MCI	Temporal	Theta	Relative power	551	139	139	36	62	17
MCI	Parieto-occipital	Beta	Relative power	2525	632	632	159	282	71
AD dementia	Parieto-occipital	-	Peak frequency	1023	235	235	62	108	28
AD dementia	Temporal	Theta	PE	3436	1023	1023	257	429	115

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