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Table 2 Neuropsychological assessment and other clinical indicators of included participants

From: Identification of novel diagnostic panel for mild cognitive impairment and Alzheimer’s disease: findings based on urine proteomics and machine learning

 

AD

MCI

CN

p

Global cognition

 MMSE

15 (9.5, 19)

24 (22, 26)

27 (26, 28)

< 0.001ab

 MoCA

7 (4, 12)

18 (13.75, 21)

23 (21, 26)

< 0.001ab

 ADL

36.5 (29, 49.75)

20 (20, 23)

20 (20, 20)

< 0.001a

Memory

 RAVLT-I

8.5 (2, 16.25)

20.5 (14.75, 24.25)

32.5 (26.75, 41.5)

< 0.001ab

 RAVLT-D

0 (0, 0)

0 (0, 0)

6 (4, 8)

< 0.001ab

Executive function

 DST-Backward

3 (1.5, 3)

3 (3, 4)

4 (3, 4)

< 0.001ab

 SCWT

24 (7, 41)

46 (38, 49)

50 (46.25, 50)

< 0.001ab

Attention

 DST-Forward

7 (6, 8)

8 (6.75, 9)

8.5 (8, 9)

< 0.001a

 SDMT

0 (0, 7.75)

20 (13.5, 29)

28 (20, 39.25)

< 0.001ab

Language

 BNT

10 (7, 16.25)

19 (15, 23)

26 (23, 27.25)

< 0.001ab

 VFT

15 (8.75, 21)

26 (23, 34)

40 (34, 49)

< 0.001ab

Visuospatial ability

 CDT

5 (1, 17)

22 (15, 28)

26 (24, 30)

< 0.001ab

 RCFT

0 (0, 0)

2 (0, 8.5)

11 (5, 17)

< 0.001ab

 qEEG (abnormal%)

64.6

51.5

35.9

0.041a

 MTA-Left

3 (2, 3)

1.5 (1, 2)

0 (0, 1)

< 0.001a

 MTA-Right

2 (2, 3)

1 (1, 1.75)

0 (0, 1)

< 0.001a

  1. MMSE Mini-Mental Status Examination, MoCA Montreal Cognitive Assessment, ADL Activity of Daily Living Scale, RAVLT-I Rey Auditory Verbal Learning Test-Immediate, RAVLT-D Rey Auditory Verbal Learning Test-Delay, DST Digit Span Test, SCWT Stroop Color and Word Test, TMT Trail Making Test, SDMT Symbol Digit Modalities Test, BNT Boston Naming Test, VFT Verbal Fluency Test, CDT Clock Drawing Test, RCFT Rey Complex Figure Test, qEEG quantitative electroencephalography, MTA Medial Temporal Lobe Atrophy Scale
  2. aSignificant differences between AD and CN (Bonferroni-corrected p < 0.05)
  3. bSignificant differences between MCI and CN (Bonferroni-corrected p < 0.05)