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Fig. 5 | Alzheimer's Research & Therapy

Fig. 5

From: Long-term normalization of calcineurin activity in model mice rescues Pin1 and attenuates Alzheimer’s phenotypes without blocking peripheral T cell IL-2 response

Fig. 5

Treated APP/PS1 mice show improved water maze performance. A Platform acquisition time during training from each of the four groups of mice. n = 7–12 per group, 4 trials per mouse per day. * = p < 0.05 by a two-way ANOVA with uncorrected Fisher’s LDS with a single pooled variance. Significance is between WT and APP/PS1 mice at trial days 6 and 7. B Crossings from the probe trial for each of the four groups of mice. n = 7–12 per group. * = p < 0.05 by a one-way ANOVA with Tukey. C Percent time spent in correct Water Maze quadrant n = 7–12 per group. * = p < 0.05 by a one-way ANOVA with Tukey. D Swim speed in Water Maze. n = 7–12 per group. * = p < 0.05 by a one-way ANOVA with Tukey. For all graphs, WT (blue), WT + FK506 (green), APP/PS1 (red), and APP/PS1 + FK506 (purple)

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Alzheimer's Research & Therapy

ISSN: 1758-9193