Table 2 Cross-sectional associations between tau biomarkers and downstream measures of neurodegeneration and cognitive impairment

A. Adj. Cort. Vol

\(\beta\)

95% CI of\(\beta\)

p

\(\beta\)

95% CI of\(\beta\)

p

\(\beta\)

95% CI of\(\beta\)

p

Age

 − 0.07

[− 0.13, − 0.02]

0.008

 − 0.04

[− 0.09, 0.002]

0.063

 − 0.08

[− 0.13, − 0.02]

0.007

Sex

1.29

[0.47, 2.12]

0.002

1.08

[0.27, 1.89]

0.010

1.31

[0.49, 2.14]

0.002

FTP SUVR

 − 1.75

[− 2.99, − 0.52]

0.006

 − 1.46

[− 2.84, − 0.09]

0.037

p-tau217

 − 1.33

[− 2.62, − 0.05]

0.043

 − 0.68

[− 2.08, 0.72]

0.336

R²

0.165

0.129

0.174

AIC

354

358

355

B. MMSE

\(\beta\)

95% CI of\(\beta\)

p

\(\beta\)

95% CI of\(\beta\)

p

\(\beta\)

95% CI of\(\beta\)

p

Age

 − 0.08

[− 0.24, 0.07]

0.302

0.06

[− 0.07, 0.19]

0.358

 − 0.10

[− 0.25, 0.05]

0.205

Sex

2.68

[0.28, 5.07]

0.029

1.75

[− 0.62, 4.12]

0.145

2.86

[− 0.58, 5.14]

0.015

FTP SUVR

 − 9.61

[− 13.18, − 6.04]

 < 0.001

 − 7.02

[− 10.78, − 3.25]

 < 0.001

p-tau217

 − 9.29

[− 13.05, − 5.53]

 < 0.001

 − 6.12

[− 10.02, − 2.26]

0.002

R²

0.328

0.299

0.402

AIC

526

530

518