Table 1 Sample characteristics
Variables | Overall N = 237 (100%) | Women N = 142 (60%) | Men N = 95 (40%) | |
|---|---|---|---|---|
Age, years | 73.3 ± 6.2 | 73.6 ± 6.6 | 72.8 ± 5.5 | |
Education | No college | 72 (30.4) | 49 (34.5) | 23 (24.2) |
Some college | 75 (31.6) | 52 (36.6) | 23 (24.2) | |
College graduate | 90 (38.0) | 41 (28.9) | 49 (51.6) | |
Current smoking | 8 (3.4) | 5 (3.5) | 3 (3.2) | |
Body mass index (kg/m2) ≥ 30 | 64 (27.0) | 40 (28.2) | 24 (25.3) | |
APOE4 positive | 46 (19.8) | 26 (18.8) | 20 (21.3) | |
Time between blood draw and cognitive assessment, years | 1.6 ± 1.0 | 1.6 ± 1.0 | 1.7 ± 1.0 | |
Global cognition performancea |  − 0.26 ± 1.1 |  − 0.14 ± 1.1 |  − 0.44 ± 1.0 | |
Brain MRI measures | ||||
 Time between blood draw and MRI, years | 1.7 ± 0.9 | 1.7 ± 1.0 | 1.7 ± 0.9 | |
 Total cerebral brain volume, % TCV | 74.1 ± 2.1 | 74.2 ± 2.1 | 74.0 ± 2.2 | |
 Gray matter volume, % TCV | 40.0 ± 1.9 | 40.4 ± 2.0 | 39.3 ± 1.7 | |
 Hippocampal volume, % TCV | 0.52 ± 0.05 | 0.52 ± 0.04 | 0.50 ± 0.04 | |
 White matter hyperintensities, % TCV | 0.3 [0.1–0.5] | 0.3 [0.1–0.6] | 0.3 [0.1–0.4] | |
Blood biomarkers | ||||
 Neurofilament light, pg/mL | 20.7 [13.9–28.0] | 21.5 [14.0–27.5] | 18.8 [13.9–28.8] | |
 Glial fibrillary acidic protein, pg/mL | 193.6 [148.4–269.4] | 209.2 [152.4–278.9] | 182.8 [131.1–249.1] | |
 Total tau, pg/mL | 1.7 [1.2–2.4] | 1.9 [1.3–2.5] | 1.4 [1.0–1.9] | |
 UCH-L1, pg/mL | 25.4 [20.7–35.9] | 25.8 [20.7–35.8] | 25.3 [20.6–37.1] | |