Diagnostic group and biomarker | Survival time | Univariate Cox regression | Multivariate Cox regressiona | |||
---|---|---|---|---|---|---|
Median ± IQR (months) | HR (95% CI) | P value | HR (95% CI) | P value | ||
Whole CJD cohort | ||||||
SNAP-25 (N = 215) | Continuous value | 5.0 (2.8–12.0) | 1.71 (1.48–1.99) | < .001 | 1.71 (1.40–2.09) | < .001 |
Low tertile | 12.0 (6.0–17.5) | Ref | Ref | Ref | Ref | |
Mid tertile | 4.0 (2.5–9.0) | 1.87 (1.34–2.61) | < .001 | 1.71 (1.19–2.44) | .003 | |
High tertile | 4.0 (2.5–5.5) | 3.42 (2.38–4.90) | < .001 | 3.42 (2.15–5.45) | < .001 | |
Ng (N = 119) | Continuous value | 6.0 (3.6–13.0) | 1.19 (0.99–1.45) | .065 | 1.04 (0.82–1.33) | .720 |
Low tertile | 7.5 (5.4–14.0) | Ref | Ref | Ref | Ref | |
Mid tertile | 6.0 (3.5–11.8) | 0.99 (0.63–1.54) | .971 | 0.80 (0.49–1.32) | .396 | |
High tertile | 4.1 (2.6–12.0) | 1.23 (0.78–1.92) | .374 | 0.93 (0.54–1.60) | .808 | |
Typical CJDb | ||||||
SNAP-25 (N = 100) | Continuous value | 2.8 (2.1–4.0) | 1.36 (1.03–1.80) | .029 | 1.52 (1.15–2.02) | .003 |
Low tertile | 3.5 (2.4–4.1) | Ref | Ref | Ref | Ref | |
Mid tertile | 2.5 (2.0–3.4) | 0.94 (0.53–1.65) | .831 | 1.03 (0.56–1.77) | .991 | |
High tertile | 2.5 (2.1–3.3) | 1.35 (0.76–2.39) | .302 | 1.65 (0.91–2.96) | .093 | |
Ng (N = 41) | Continuous value | 3.0 (2.0–4.0) | 1.50 (1.04–2.16) | .027 | 1.81 (1.21–2.93) | .015 |
Low tertile | 2.4 (1.8–4.5) | Ref | Ref | Ref | Ref | |
Mid tertile | 3.0 (2.1–3.8) | 2.48 (0.70–8.76) | .157 | 7.90 (1.28–48.71) | .026 | |
High tertile | 3.0 (2.5–3.9) | 3.59 (1.01–12.67) | .047 | 10.34 (1.71–62.34) | .011 | |
non-MM(V)1 CJDc | ||||||
SNAP-25 (N = 115) | Continuous value | 11.0 (6.0–16.0) | 1.69 (1.38–2.06) | < .001 | 1.01 (0.73–1.40) | .937 |
Low tertile | 15.0 (11.0–24.0) | Ref | Ref | Ref | Ref | |
Mid tertile | 14.8 (10.8–19.7) | 1.39 (0.88–2.19) | .147 | 1.03 (0.58–1.83) | .914 | |
High tertile | 5.5 (4.7–6.5) | 4.68 (2.81–7.78) | < .001 | 0.91 (0.36–2.29) | .844 | |
Ng (N = 78) | Continuous value | 9.5 (6.0–16.0) | 0.93 (0.76–1.15) | .547 | 0.81 (0.60–1.09) | .169 |
Low tertile | 9.0 (6.3–15.0) | Ref | Ref | Ref | Ref | |
Mid tertile | 9.0 (5.9–15.5) | 0.69 (0.41–1.15) | .164 | 0.58 (0.33–1.01) | .058 | |
High tertile | 12.0 (6.0–23.8) | 0.50 (0.26–0.94) | .034 | 0.45 (0.22–0.91) | .027 |