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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Diagnostic and prognostic value of cerebrospinal fluid SNAP-25 and neurogranin in Creutzfeldt-Jakob disease in a clinical setting cohort of rapidly progressive dementias

Fig. 2

Biomarker diagnostic performance. ROC curves for CSF SNAP-25 (purple), CSF t-tau (green), CSF 14–3-3 (red), CSF NfL (blue), and CSF Ng (orange) in the comparisons between CJD vs. np-RPD (A), atypical CJD (MV2K, MM(V)2C, MM2TM and VV1 subtypes of sCJD) vs. np-RPD (B), CJD vs. rp-ND (C), and CJD vs non-neurodegenerative np-RPD (D). CJD, Creutzfeldt-Jakob disease; CSF, cerebrospinal fluid; NfL, neurofilament light chain; Ng, neurogranin; np-RPD, non-prion rapidly progressive dementia; p-tau, phospho-tau181; ROC, receiver operating characteristic; rp-ND, neurodegenerative np-RPD; SNAP-25, synaptosomal-associated protein 25; t-tau, total tau. AUC values for Ng were calculated considering a cohort of 215 patients (122 CJD, 93 np-RPD)

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Alzheimer's Research & Therapy

ISSN: 1758-9193