A polygenic risk score for Alzheimer’s disease constructed using APOE-region variants has stronger association than APOE alleles with mild cognitive impairment in Hispanic/Latino adults in the U.S.

Table 2 Target population characteristics by Hispanic/Latino background group (survey weighted)

Characteristics	Hispanic/Latino Background
Characteristics	Central American	Cuban	Dominican	Mexican	Puerto Rican	South American
N	457	939	446	1583	820	344
Age at SOL-INCA visit (mean (sd))	62.30 (7.40)	65.20 (8.57)	62.81 (8.18)	62.04 (7.58)	63.97 (8.13)	63.38 (7.98)
Sex = M (%)	41.60	52.20	40.20	46.60	48.10	43.10
BMI (mean (sd))	30.65 (5.68)	29.63 (5.35)	30.14 (5.18)	30.07 (5.30)	30.84 (6.29)	29.18 (5.12)
Education (%)
• No high school diploma	39.40	24.10	43.60	46.20	43.30	18.50
• At most a High school diploma	19.50	24.50	19.70	21.00	20.50	20.21
• Greater than high school	41.10	51.40	36.70	32.80	36.20	61.50
Hypertension = Yes (%)	38.30	56.30	57.20	37.20	52.80	33.60
Type 2 Diabetes = Yes (%)	28.40	27.80	29.70	27.80	32.60	21.40
APOE-e4 allele carrier = Yes (%)	21.20	23.50	29.20	19.50	23.40	16.20
APOE-e2 allele carrier = Yes (%)	7.40	11.6	18.80	5.10	9.70	5.50
Prop of European ancestry (mean (SD))	0.46 (0.15)	0.80 (0.21)	0.48 (0.15)	0.46 (0.20)	0.65 (0.12)	0.50 (0.22)
MCI = Yes (%)	11.70	11.00	12.60	10.40	12.80	8.00
G-Factor change (mean (SD))	-0.09 (0.85)	-0.08 (0.97)	-0.08 (0.85)	-0.21 (0.84)	-0.18 (0.85)	-0.07 (0.93)
Word frequency change (mean (SD))	-0.56 (5.34)	-0.28 (5.74)	0.52 (5.57)	-0.93 (5.44)	0.15 (5.21)	-0.75 (5.76)
SEVLT recall change (mean (SD))	0.28 (2.95)	0.28 (3.01)	-0.13 (2.89)	-0.10 (2.87)	-0.26 (2.93)	-0.01 (3.16)
Digit symbol change (mean (SD))	-2.22 (7.41)	-2.22 (8.28)	-2.06 (6.93)	-2.51 (6.84)	-2.78 (7.93)	-0.26 (7.35)

The table characterizes the target population represented by the study participants. All means, standard deviations (SDs), and percentages, were computed while accounting for survey design

ISSN: 1758-9193