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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: A polygenic risk score for Alzheimer’s disease constructed using APOE-region variants has stronger association than APOE alleles with mild cognitive impairment in Hispanic/Latino adults in the U.S.

Fig. 2

Estimated effect sizes and confidence intervals of PRSsum based on AD GWASs in association with MCI. PRSsum was constructed as the unweighted sum of 5 standardized PRSs, each based on a separate GWAS described in Table 1. For each GWAS, the PRSs were selected based on optimizing the coefficient of variation across 4 independent subsets of the SOL-INCA dataset. We provide the estimated effect size (odds ratio), 95% confidence interval, and p-value (computed based on the Score test) in models based on the complete dataset (“All”), by Hispanic/Latino background, and for the subsets of people with at least 20% global proportion of African, Amerindian, and European ancestries. The PRS associations were estimated in models adjusted for age at the HCHS/SOL baseline visit, time from HCHS/SOL baseline to the SOL-INCA visit, sex, study center, 5 principal components, and APOE-\(\epsilon 4\) and APOE-\(\epsilon 2\) allele counts

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Alzheimer's Research & Therapy

ISSN: 1758-9193