Table 2 Summary of network changes in APP/PS1 mice, in human pre-symptomatic and in human symptomatic AD
From: Neurophysiological alterations in mice and humans carrying mutations in APP and PSEN1 genes
LFP/MEG parameter | APP/PS1 mice | Mutation carriers | Symptomatic ADa |
|---|---|---|---|
Total power | |||
 (Pre)frontal cortex | Unchanged | Unchanged | Unknown |
 Parietal cortex | Increased (3–6 moa) | Unchanged | Unknown |
 Hippocampus | Increased (3–6 moa) | Unchanged | Increased |
Absolute power | |||
 (Pre)frontal cortex | Unchanged | Unchanged | Increased δ, θ |
 Parietal cortex | Increased θ, α, β, γ1, γ2 (3–6 moa) | Unchanged | Increased δ, θ, in-/decreased α, decreased β |
 Hippocampus | Increased δ, θ, α, β, γ1, γ2 (3–6 moa) | unchanged | Increased θ, in-/decreased α, decreased β |
Relative power | |||
 (Pre)frontal cortex | Decreased θ, increased β, γ1 (3–12 moa) | Unchanged | Increased θ, increased α, decreased β |
 Parietal cortex | Decreased θ, increased β, γ1 (3–12 moa) | Unchanged | Increased δ, θ, in-/decreased α, decreased β |
 Hippocampus | Increased β (3–12 moa) | Increased θ | Increased θ, decreased α, β |
Peak frequency | |||
 Parietal cortex | Unchanged | Decreased α peak frequency | Decreased α peak frequency |
 Hippocampus | Unchanged | Decreased α peak frequency | Decreased α peak frequency |
Phase-based connectivity | |||
 (Pre)frontal-parietal | Decreased θ, α wPLI (6–12 moa) | Unchanged | Unchanged (suggested increased θ, in-/decreased α) |
 (Pre)frontal-hippocampal | Decreased θ, α wPLI (6–12 moa) | Increased γ wPLI | Unchanged (suggested increased θ) |
Amplitude-based connectivity | |||
 (Pre)frontal-parietal | Unchanged | Decreased β AECc | Decreased α, β |
 (Pre)frontal-hippocampal | Increased β AECc (9–12 moa) | Decreased β AECc | Decreased α, β |