Neurophysiological alterations in mice and humans carrying mutations in APP and PSEN1 genes

Table 1 Demographics and neuropsychological data for human subjects

	Mutation carriers	Healthy controls	P value
N	11	33	-
Age (years)	49 [20–61]	49 [20–62]	0.957
Female/male (n)	8/3	24/9	> 0.999
PSEN1/APP (n)	9/2	-	-
Education (Verhage)	6 [5–7]	6 [1–7]	0.742
Global cognition (MMSE)	29 [27–30] (n = 11)	27 [27–30] (n = 7)	0.375
Estimated years before symptom onset	1 [− 16–22]	-	-

Group median and range are presented unless otherwise specified. Education is presented in Verhage score (range 1–7); MMSE, Mini-Mental State Examination (max 30); negative values for estimated years before symptom onset indicate that subjects had passed the estimated age of symptom onset

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