Fig. 4
From: Neurophysiological alterations in mice and humans carrying mutations in APP and PSEN1 genes
AD-related changes in peak frequency in awake moving APP/PS1 mice and human mutation carriers. In the legend, ^ refers to a significant main effect of genotype; * refers to a significant interaction effect of genotype × time. Significant results from uncorrected two-sample tests are depicted by red bars on the x-axis. a Mean PSD for theta frequencies over which theta (5–10 Hz) peak frequency was calculated in 3-month-old (left) and 12-month-old (right) mice in the parietal cortex. b Mean theta peak frequency over the 9-month recording period in the parietal cortex. Mixed-effects analysis did not show a main effect of genotype or a genotype × time interaction effect. c Mean PSD for theta frequencies in 3-month-old (left) and 12-month-old (right) mice in the hippocampus. d Mean theta peak frequency over the 9-month recording period in the hippocampus. Mixed-effects analysis did not show a main effect of genotype or a genotype × time interaction effect. e Left: mean PSD for the parietal cortex of human mutation carriers and healthy controls. Right: alpha (8–13 Hz) peak frequency is reduced in mutation carriers compared to healthy control subjects in the parietal cortex (W = 2.700, p = 0.00694). f Left: mean PSD for the hippocampus of human mutation carriers and healthy controls. Right: alpha peak frequency is reduced in mutation carriers compared to healthy control subjects in the hippocampus (W = 2.172, p = 0.0299)