Fig. 3

AD-related changes in relative power in APP/PS1 mice and human mutation carriers. In the legend, ^ refers to a significant main effect of genotype; * refers to a significant interaction effect of genotype × time. Significant results from uncorrected two-sample tests are depicted by red bars on the x-axis. a–c Mean PSD for 3-month-old (left) and 12-month-old (right) mice in the prefrontal cortex (a), parietal cortex (b), and hippocampus (c). d–f Mean relative power per frequency band over the 9-month LFP recording period in the prefrontal cortex (θ: ^; β: ^, γ1: ^) (d), in the parietal cortex (θ: ^; β: ^*, γ1: ^, γ2: *) (e), and in hippocampus (δ: *, β: ^, γ2: ^) (f). g Mean PSD in the frontal cortex (left), parietal cortex (middle), and hippocampus (right) for mutation carriers (MC) and healthy controls (HC). h Quantification of relative power in the frontal cortex (left), parietal cortex (middle), and hippocampus (right) of human mutation carriers per frequency band. No changes in relative power were detected in the frontal cortex (δ: W =  − 0.542, p = 0.588; θ: W =  − 1.680, p = 0.0929; α: W = 1.464, p = 0.143; β: W = 1.464, p = 0.143; γ1: W = 0.0271, p = 0.978; γ2: W =  − 0.0542, p = 0.957) or in the parietal cortex (δ: W =  − 0.190, p = 0.850; θ: W =  − 1.301, p = 0.193; α: W = 1.166, p = 0.244; β: W =  − 0.217, p = 0.828; γ1: W = 0.623, p = 0.533; γ2: W = 0.407, p = 0.684). In the hippocampus, power was increased in the theta frequency range, but not in other frequency ranges (δ: W =  − 0.596, p = 0.551; θ: W =  − 2.0599, p = 0.0394; α: W = 1.626, p = 0.104; β: W = 0.0271, p = 0.978; γ1: W = 0.379, p = 0.704; γ2: W = 0.949, p = 0.343)