Fig. 2

AD-related changes in absolute power per frequency band in APP/PS1 mice and human mutation carriers. In the legend, ^ refers to a significant main effect of genotype; * refers to a significant interaction effect of genotype × time. Significant results from uncorrected two-sample tests are depicted by red bars on the x-axis. a–c Mean absolute power per frequency band over the 9-month LFP recording period in the prefrontal cortex (β: ^*, γ1: ^) (a), in parietal cortex (θ: *, α: *, β: *, γ1: *) (b), and in hippocampus (δ: *, θ: *, α: *, β: *, γ1: *, γ2: *) (c). Frequency bands from left to right: delta (1–5 Hz), theta (5–10 Hz), alpha (10–13 Hz), beta (13–30 Hz), low gamma (30–60 Hz), and high gamma (60–120 Hz). d Quantification of absolute MEG power per frequency band in the frontal cortex (left), parietal cortex (middle), and hippocampus (right) in mutation carriers (MC) and healthy controls (HC). No changes in total absolute power were detected in the prefrontal cortex (δ: W = 0.867, p = 0.386; θ: W =  − 0.203, p = 0.839; α: W = 0.830, p = 0.406; β: W = 1.568, p = 0.117; γ1: W = 0.646, p = 0.519; γ2: W = 0.498, p = 0.618), parietal cortex (δ: W = 0.0184, p = 0.985; θ: W =  − 0.793, p = 0.428; α: W = 0.756, p = 0.449; β: W = 0.0922, p = 0.927; γ1: W =  − 0.461, p = 0.645; γ2: W = 0.0553, p = 0.956) or hippocampus (δ: W =  − 0.646, p = 0.519; θ: W =  − 1.310, p = 0.190; α: W = 0.535, p = 0.593; β: W = 0.0184, p = 0.985; γ1: W =  − 0.424, p = 0.671; γ2: W = 0.129, p = 0.897). Frequency bands from left to right: delta, (1–4 Hz), theta (4–8 Hz), alpha (8–13 Hz), beta (13–30 Hz), low gamma (30–60 Hz), and high gamma (60–100 Hz)