Fig. 1

AD-related changes in total absolute power in APP/PS1 mice and human mutation carriers. For figure legends, ^ refers to a significant main effect of genotype; * refers to a significant interaction effect of genotype × time. Significant results from uncorrected two-sample tests are depicted by red bars on the x-axis. a LFP electrodes were located in the prefrontal cortex (green), parietal cortex (orange), and hippocampus (blue). A reference screw was placed at the cerebellum. b LFP example traces from the prefrontal cortex (green), parietal cortex (orange), and hippocampus (blue). c-d Mean PSD for 3-month-old (left) and 12-month-old (right) mice in the prefrontal cortex (c), parietal cortex (d), and hippocampus (e). Note the prominent theta (5–10 Hz) peak in the parietal cortex and hippocampus. f Total absolute power (summed power over 1–120 Hz) in the prefrontal cortex (top), parietal cortex (middle), and hippocampus (bottom) in 3–12-month-old APP/PS1 (TG) and wildtype (WT) mice. Parietal cortex: *; hippocampus: *. g Graphical representation of MEG recordings in human participants. h Example traces of MEG recordings from the frontal cortex (green), parietal cortex (orange), and hippocampus (blue). i Mean PSD in the frontal cortex (top), parietal cortex (middle), and hippocampus (bottom) for mutation carriers (MC) and healthy controls (HC). Note the alpha (8–13 Hz) peak in the parietal cortex and hippocampus. j Total absolute power (summed power over 1–100 Hz) in the frontal cortex (top), parietal cortex (middle), and hippocampus (bottom) in APP and PSEN1 mutation carriers. No changes in total absolute power were detected in the prefrontal cortex (W = 1.273, p = 0.203), parietal cortex (W = 0.350, p = 0.726), or hippocampus (W =  − 0.277, p = 0.782)