Table 3 Comparison of robust NODDI z-scores between CU and MCI/AD clinical status participants

Superior frontal gyrus

0.11

0.28 (− 0.09–0.58)

0.002^b

0.54 (0.17–0.78)^d

Hippocampus

0.0061^b

0.49 (0.002–0.79)^d

0.001^b

0.58 (0.13–0.83)^d

Posterior cingulate gyrus

0.014^a

0.44 (− 0.005–.73)

0.06

0.38 (− 0.018–0.67)

Inf. parietal + precuneus

0.15

0.25 (− 0.19–0.61)

0.00042^c

0.63 (0.25–0.84)^d

Parahippocampus

0.06

0.38 (− 0.13–0.73)

0.021^a

0.41 (− 0.0150–0.71)

Temporal inferior

0.19

0.23 (− 0.22–0.60)

0.0026^b

0.53 (0.06–0.81)^d

WM ROIs (bilateral)

Uncinate fasciculus

0.059

0.33 (− 0.02–0.61)

0.003^b

 − 0.53 (− 0.78 to − 0.13)^d

Superior longitudinal fasciculus

0.08

0.31 (− 0.09–0.63)

0.614

0.09 (− 0.25–0.41)

Inferior longitudinal fasciculus

0.017^a

0.43 (0.04–0.70)^d

0.042^a

0.36 (− 0.018–0.65)

Cingulum (hippocampus)

0.03^a

0.44 (0.16–0.65)^d

0.01^a

 − 0.45 (− 0.68 to − 0.14)^d

Cingulum (cingulate gyrus)

0.005^a

0.50 (1.10–0.76)^d

0.74

0.06 (− 0.41–0.31)

Forceps major

0.068

0.32 (− 0.07–0.63

0.92

0.017 (− 0.35–0.322)