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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Neuroimaging of tissue microstructure as a marker of neurodegeneration in the AT(N) framework: defining abnormal neurodegeneration and improving prediction of clinical status

Fig. 3

Distribution of NODDI metric z-scores across CU and MCI/AD clinical diagnosis groups for all ROIs. Boxplots displaying median, 25th quartile, and 75.th quartile NDI or ODI z-scores and NDI or ODI values, respectively, for each ROI across CU and MCI/AD clinical status groups. NODDI-NDI and NODDI-ODI z-scores were developed using robust normative analysis in R as described. Box plot color corresponds to the clinical status group (gray = CU; blue = MCI/AD). ODI or NDI z-scores are labeled on the left Y-axis. On the right Y-axis are the raw NDI or ODI values corresponding to each z-score quartile. * indicates a significant difference in NDI z-score distribution between clinical diagnosis groups. “*” = P < 0.05, “**” = P < 0.01, “***” = P < 0.001, Kruskal–Wallis)

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Alzheimer's Research & Therapy

ISSN: 1758-9193