Table 3 Association of polygenic risk scores with Alzheimer’s disease, all-cause dementia, and blood biomarkers stratified by APOE status
APOE4 + | APOE4- | ||||||
|---|---|---|---|---|---|---|---|
Total n | Cases n | OR (95% CI) p-value | Total n | Cases n | OR (95% CI) p-value | Interaction p-value | |
Alzheimer’s disease | |||||||
Kunkle PRS per SD increase | 1375 | 76 | 1.45 (1.17–1.79) .0006 | 4046 | 76 | 0.72 (0.49–1.07) .12 | .001 |
Bellenguez PRS per SD increase | 1375 | 76 | 1.49 (1.16–1.92) .002 | 4046 | 76 | 0.94 (0.75–1.19) .62 | < .01 |
All-cause dementia | |||||||
Kunkle PRS per SD increase | 1480 | 181 | 1.22 (1.06–1.42) .008 | 4250 | 280 | 0.84 (0.72–0.99) .04 | < .001 |
Bellenguez PRS per SD increase | 1480 | 181 | 1.35 (1.14–1.61) .0007 | 4250 | 280 | 0.93 (0.82–1.06) .27 | < .001 |
P-tau181 | beta (p-value) | beta (p-value) | |||||
Kunkle PRS per SD increase | 224 | -0.02 (.52) | 486 | -0.005 (.88) | .71 | ||
Bellenguez PRS per SD increase | 224 | 0.004 (.91) | 486 | -0.01 (.60) | .40 | ||
NfL | |||||||
Kunkle PRS per SD increase | 224 | -0.002 (.95) | 483 | -0.03 (.16) | .14 | ||
Bellenguez PRS per SD increase | 224 | 0.01 (.65) | 483 | -0.02 (.28) | .08 | ||
GFAP | |||||||
Kunkle PRS per SD increase | 224 | 0.02 (.44) | 483 | 0.02 (.57) | .42 | ||
Bellenguez PRS per SD increase | 224 | 0.05 (.19) | 483 | 0.03 (.13) | .12 | ||