Table 1 Baseline characteristics
|  | PA | EHa | p-value†| ||
|---|---|---|---|---|---|
Total (N = 3687) | ADX (N = 1339) | MRA (N = 2348) | control (N = 14741) | ||
Age, mean (SD) | 56.27 ± 10.86 | 51.90 ± 8.06 | 58.77 ± 11.44‡ | 56.26 ± 10.83 | 0.936 |
Sex (male) | 1755 (47.6) | 574 (42.87) | 1181 (50.3) | 7019 (47.62) | 0.986 |
Index year, n (%) | Â | Â | Â | Â | 0.999 |
 2003 | 67 (2.85) | 49 (3.66) | 116 (3.15) | 460 (3.12) |  |
 2004 | 92 (3.92) | 55 (4.11) | 147 (3.99) | 588 (3.99) |  |
 2005 | 93 (3.96) | 54 (4.03) | 147 (3.99) | 588 (3.99) |  |
 2006 | 89 (3.79) | 52 (3.88) | 141 (3.82) | 564 (3.83) |  |
 2007 | 113 (4.81) | 77 (5.75) | 190 (5.15) | 757 (5.14) |  |
 2008 | 144 (6.13) | 76 (5.68) | 220 (5.97) | 880 (5.97) |  |
 2009 | 129 (5.49) | 88 (6.57) | 217 (5.89) | 868 (5.89) |  |
 2010 | 165 (7.03) | 95 (7.09) | 260 (7.05) | 1040 (7.06) |  |
 2011 | 207 (8.82) | 101 (7.54) | 308 (8.35) | 1232 (8.36) |  |
 2012 | 173 (7.37) | 108 (8.07) | 281 (7.62) | 1124 (7.62) |  |
 2013 | 195 (8.30) | 116 (8.66) | 311 (8.44) | 1244 (8.44) |  |
 2014 | 258 (10.99) | 123 (9.19) | 381 (10.33) | 1524 (10.34) |  |
 2015 | 214 (9.11) | 132 (9.86) | 346 (9.38) | 1384 (9.39) |  |
 2016 | 283 (12.05) | 146 (10.90) | 429 (11.64) | 1716 (11.64) |  |
 2017 | 126 (5.37) | 67 (5.00) | 193 (5.23) | 772 (5.24) |  |
Social economic status | |||||
 Lower 30% | 1678 (46.32) | 626 (47.5) | 1052 (45.64)‡ | 5557 (38.56) |  < 0.001 |
 Middle 40% | 1110 (30.64) | 424 (32.17) | 686 (29.76)‡ | 4985 (34.59) |  < 0.001 |
 Highest 30% | 835 (23.05) | 268 (20.33) | 567 (24.6)‡ | 3868 (26.84) |  < 0.001 |
Comorbidity, n (%) | |||||
 Diabetes | 2540 (68.89) | 838 (62.58) | 1702 (72.49)‡ | 5896 (40) |  < 0.001 |
 Dyslipidemia | 3095 (83.94) | 1098 (82) | 1997 (85.05)‡ | 8949 (60.71) |  < 0.001 |
 Chronic kidney disease | 280 (7.59) | 86 (6.42) | 194 (8.26) | 164 (1.11) |  < 0.001 |
 Atrial fibrillation | 413 (11.2) | 77 (5.75) | 336 (14.31)‡ | 324 (2.2) |  < 0.001 |
 Non-fatal MI | 524 (14.21) | 111 (8.29) | 413 (17.59)‡ | 624 (4.23) |  < 0.001 |
 Non-fatal stroke | 331 (8.98) | 95 (7.09) | 236 (10.05)‡ | 505 (3.43) |  < 0.001 |
Medication, n (%) | |||||
 ARB/ACE inhibitor | 3090 (83.81) | 1159 (86.56) | 1931 (82.24)‡ | 9242 (62.7) |  < 0.001 |
 β-blocker | 2788 (75.62) | 1024 (76.47) | 1764 (75.13)‡ | 3292 (22.33) |  < 0.001 |
 CCB | 3291 (89.26) | 1295 (96.71) | 1996 (85.01) | 8554 (58.03) |  < 0.001 |
 Diuretics | 3567 (96.75) | 1251 (93.43) | 2316 (98.64)‡ | 5122 (34.75) |  < 0.001 |
 Statins | 1687 (45.76) | 512 (38.24) | 1175 (50.04)‡ | 4898 (33.23) |  < 0.001 |
 Antithrombotics | 1971 (53.46) | 635 (47.42) | 1336 (56.9)‡ | 3566 (24.19) |  < 0.001 |