Table 2 Cognitive changes during 24 months

At 12 months

 DST-Forward_percentile

63.475 ± 31.659

65.739 ± 30.784

0.777

 K-BNT_percentile

59.491 ± 26.719

64.559 ± 32.940

0.475

 RCFT Copy_percentile

51.246 ± 25.419

60.095 ± 18.986

0.156

 SVLT delayed recall_percentile

47.467 ± 26.922

30.507 ± 25.009

0.013

 RCFT delayed recall_percentile

52.414 ± 30.292

52.541 ± 28.228

0.987

 Digit symbol constitution_score

65.205 ± 26.403

64.417 ± 30.637

0.909

 COWAT phonemic_percentile

54.044 ± 27.552

60.327 ± 32.563

0.386

 K-TMT-B_percentile

62.677 ± 23.257

49.680 ± 28.259

0.036

 K-stroop color reading_percentile

60.766 ± 25.958

53.286 ± 31.261

0.276

 K-MMSE score

27.765 ± 1.968

27.158 ± 2.292

0.241

At 24 months

 DST-Forward_percentile

68.293 ± 28.429

62.637 ± 31.599

0.434

 K-BNT_percentile

65.726 ± 27.441

56.719 ± 37.362

0.221

 RCFT Copy_percentile

52.100 ± 25.450

55.395 ± 23.359

0.597

 SVLT delayed recall_percentile

51.010 ± 25.863

31.738 ± 23.934

0.003

 RCFT delayed recall_percentile

58.345 ± 29.150

52.692 ± 28.664

0.435

 Digit symbol constitution_score

68.433 ± 25.238

61.783 ± 34.289

0.325

 COWAT phonemic_percentile

55.173 ± 29.411

59.796 ± 30.297

0.530

 K-TMT-B_percentile

67.452 ± 21.089

45.566 ± 26.767

< 0.001

 K-stroop color reading_percentile

60.524 ± 28.679

53.032 ± 27.412

0.291

    K-MMSE score

28.047 ± 1.775

26.700 ± 2.830

0.054