Table 1 Demographics and clinical features of the selected cohort
Variable | Overall | SCD | MCI | pre-AD | MCI-AD | ADdem | FTD |
|---|---|---|---|---|---|---|---|
n | 233 | 52 | 30 | 19 | 50 | 45 | 37 |
Age (years) mean ± SD | 70.5 ± 7.8 | 65.5 ± 9.0 | 71.0 ± 8.1 | 73.6 ± 5.8 | 72.5 ± 5.9 | 74.0 ± 6.4 | 68.4 ± 6.4 |
Sex (male) n (%) | 99 (42.5) | 28 (53.8) | 14 (46.7) | 6 (31.6) | 16 (32.0) | 15 (33.3) | 20 (54.1) |
MMSE median [IQR] | 25.0 [22.0, 28.0] | 28.0 [27.8, 29.0] | 25.0 [23.2, 28.0] | 27.0 [27.0, 28.5] | 24.0 [22.0, 27.0] | 15.0 [11.0, 19.0] | 25.0 [23.0, 26.0] |
Years of Education mean ± SD | 9.4 ± 4.6 | 10.9 ± 4.3 | 9.0 ± 5.0 | 12.2 ± 3.5 | 9.1 ± 4.8 | 7.6 ± 3.8 | 9.5 ± 4.5 |
ATN profile, n (%) | |||||||
A-T-N- | 73 (31.3) | 38 (73.1) | 17 (56.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 18 (48.6) |
A + T-N- | 14 (6.0) | 3 (5.8) | 4 (13.3) | 0 (0.0) | 0 (0.0) | 1 (2.2) | 6 (16.2) |
A + T + N- | 14 (6.0) | 0 (0.0) | 0 (0.0) | 7 (36.9) | 7 (14.0) | 0 (0.0) | 0 (0.0) |
A + T + N + | 96 (41.2) | 0 (0.0) | 0 (0.0) | 12 (63.2) | 42 (84.0) | 44 (97.8) | 0 (0.0) |
A-T-N + | 5 (2.1) | 1 (1.9) | 2 (6.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 2 (5.4) |
A-T + N- | 15 (6.4) | 6 (11.5) | 5 (16.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 4 (10.8) |
A-T + N + | 14 (7.0) | 4 (7.7) | 2 (6.7) | 0 (0.0) | 1 (2.0) | 0 (0.0) | 7 (18.9) |
AD profile, n (%) | |||||||
Normal AD biomarkers | 73 (31.3) | 38 (73.1) | 17 (56.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 18 (48.6) |
AD pathologic change | 14 (6.0) | 3 (5.8) | 4 (13.3) | 0 (0.0) | 0 (0.0) | 1 (2.2) | 6 (16.2) |
AD profile | 112 (48.0) | 0 (0.0) | 0 (0.0) | 19 (100.0) | 49 (98.0) | 44 (97.8) | 0 (0.0) |
Non-AD pathologic change | 34 (15.6) | 11 (21.2) | 9 (30.0) | 0 (0.0) | 1 (2.0) | 0 (0.0) | 13 (35.1) |