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Table 2 Association between baseline amyloid-PET and tau-PET and change in FAQ scores over time, in binomial models

From: Regional cerebral tau predicts decline in everyday functioning across the Alzheimer’s disease spectrum

 

All

Cognitively normal

Symptomatic

OR [95%CI]

p

OR [95%CI]

p

OR [95%CI]

p

Model 1: only amyloid-PET

 Centiloids

1.00 [1.00, 1.01]

 < 0.001

1.00 [1.00, 1.01]

0.474

1.00 [1.00, 1.01]

 < 0.001

Model 2: only tau-PET

 Entorhinal

2.65 [1.92, 3.66]

 < 0.001

5.60 [1.35, 23.23]

0.035

2.35 [1.72, 3.21]

 < 0.001

 Inferior temporal

2.21 [1.72, 2.84]

 < 0.001

5.02 [1.46, 17.25]

0.022

2.00 [1.57, 2.55]

 < 0.001

 Precuneus

2.36 [1.73, 3.22]

 < 0.001

4.86 [0.77, 30.59]

0.162

2.12 [1.58, 2.85]

 < 0.001

 Posterior cingulate

3.07 [2.09, 4.51]

 < 0.001

2.29 [0.03, 13.83]

0.474

2.82 [1.95, 4.09]

 < 0.001

 Supramarginal

2.71 [1.86, 3.95]

 < 0.001

6.27 [1.03, 38.30]

0.085

2.39 [1.66, 3.43]

 < 0.001

 DLPF

2.85 [1.95, 4.14]

 < 0.001

3.17 [0.31, 32.13]

0.448

2.62 [1.83, 3.74]

 < 0.001

Model 3: tau-PET, adjusted for amyloid-PET

 Entorhinal

2.38 [1.62, 3.49]

 < 0.001

4.93 [1.06, 22.99]

0.081

2.04 [1.40, 2.99]

 < 0.001

 Inferior temporal

1.93 [1.47, 2.55]

 < 0.001

4.53 [1.31, 15.66]

0.035

1.73 [1.32, 2.28]

 < 0.001

 Precuneus

1.94 [1.39, 2.71]

 < 0.001

2.89 [0.39, 21.20]

0.423

1.79 [1.30, 2.47]

 < 0.001

 Posterior cingulate

2.52 [1.68, 3.77]

 < 0.001

1.58 [0.24, 10.35]

0.701

2.37 [1.60, 3.51]

 < 0.001

 Supramarginal

2.09 [1.40, 3.13]

 < 0.001

3.37 [0.49, 23.31]

0.336

1.91 [1.29, 2.83]

0.003

 DLPF

2.22 [1.50, 3.30]

 < 0.001

1.34 [0.12, 15.43]

0.843

2.14 [1.46, 3.12]

 < 0.001

Model 4: tau-PET by amyloid-PET by time three-way interaction

 Entorhinal

1.00 [0.99, 1.00]

0.444

0.99 [0.95, 1.03]

0.591

1.00 [0.99, 1.00]

0.423

 Inferior temporal

1.00 [0.99, 1.00]

0.423

0.98 [0.94, 1.01]

0.336

1.00 [0.99, 1.00]

0.618

 Precuneus

0.99 [0.99, 1.00]

0.083

0.98 [0.94, 1.03]

0.626

0.99 [0.99, 1.00]

0.192

 Posterior cingulate

1.00 [0.99, 1.01]

0.618

0.98 [0.94, 1.03]

0.618

1.00 [0.99, 1.01]

0.713

 Supramarginal

1.00 [0.99, 1.01]

0.773

0.98 [0.93, 1.03]

0.474

1.00 [0.99, 1.01]

0.880

 DLPF

0.99 [0.98, 1.00]

0.300

0.98 [0.92, 1.05]

0.652

0.99 [0.99, 1.00]

0.336

  1. The outcome variable for all models is the degree of impairment measured as the proportion of the maximum attainable score on the FAQ (total score / 30). Displaying amyloid-PET or tau-PET by time interactions. P-values are corrected for multiple testing. All models are adjusted for age, gender, the interaction of age with time, RAVLT, AmNART and TMT-B
  2. Abbreviations: DLPF Dorsolateral prefrontal cortex, FAQ Functional Activities Questionnaire, OR Odds ratio, 95%CI 95% confidence interval
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Alzheimer's Research & Therapy

ISSN: 1758-9193