All | Cognitively normal | Symptomatic | P-value | |
---|---|---|---|---|
N (%) | 581 (100.0) | 334 (57.5) | 247 (42.5) | |
Age in years | 73.9 ± 7.6 | 72.9 ± 7.2 | 75.1 ± 8.0 | < 0.001 |
Female, n (%) | 304 (52.3) | 201 (60.2) | 103 (41.7) | < 0.001 |
Years of education | 16.5 ± 2.5 | 16.7 ± 2.3 | 16.1 ± 2.7 | 0.024 |
Race, n (%) | 0.220 | |||
White | 534 (91.9) | 300 (89.9) | 234 (94.7) | |
Black, African American | 25 (4.3) | 18 (5.4) | 7 (2.8) | |
Asian | 8 (1.4) | 6 (1.8) | 2 (0.8) | |
American Indian, Alaskan Native | 2 (0.3) | 2 (0.6) | 0 (0.0) | |
Multiracial | 11 (1.9) | 8 (2.4) | 3 (1.2) | |
Hispanic/Latino Ethnicity, n (%) | 27 (4.6) | 19 (5.7) | 8 (3.2) | 0.164 |
Baseline FAQ | 2.4 ± 5.0 | 0.2 ± 0.9 | 5.3 ± 6.6 | < 0.001 |
MMSE | 28.2 ± 2.3 | 29.1 ± 1.2 | 27.0 ± 2.8 | < 0.001 |
AmNART VIQ | 119.9 ± 10.9 | 121.7 ± 10.3 | 117.4 ± 11.3 | < 0.001 |
Amyloid-PET | ||||
Centiloids | 32.1 ± 40.8 | 23.3 ± 31.7 | 44.3 ± 48.1 | < 0.001 |
Positive, n (%) | 259 (44.6) | 125 (37.4) | 134 (54.3) | < 0.001 |
Tau-PET | ||||
Entorhinal | 1.22 ± 0.22 | 1.15 ± 0.13 | 1.32 ± 0.28 | < 0.001 |
Inferior temporal | 1.29 ± 0.27 | 1.22 ± 0.14 | 1.38 ± 0.36 | < 0.001 |
Precuneus | 1.17 ± 0.21 | 1.12 ± 0.10 | 1.23 ± 0.29 | < 0.001 |
Posterior cingulate | 1.14 ± 0.17 | 1.11 ± 0.10 | 1.18 ± 0.23 | < 0.001 |
Supramarginal | 1.12 ± 0.17 | 1.09 ± 0.10 | 1.17 ± 0.23 | < 0.001 |
DLPF | 1.07 ± 0.17 | 1.04 ± 0.09 | 1.11 ± 0.24 | 0.002 |
Follow-up duration in years | 2.5 ± 1.2 | 2.6 ± 1.0 | 2.5 ± 1.3 | 0.067 |