Table 1 The role of miR-155 in Alzheimer’s disease: evidence from non-modifiable and modifiable risk factors

Aβ_1–42 oligomers-treated HT-22 cells

N/A

N/A

Serve as an AD detector

[22]

APP/PS1 mice, Aβ1-42-treated N2a cells

SKP2

SKP2/IKKβ pathway

Aggravating Aβ deposition

[45]

Intravitreal injection of Aβ oligomers

N/A

TGF-β and prion diseases pathways

Regulating Aβ-induced retinal damage

[49]

3xTg-AD mice

SOCS-1

TNFSF10/miRNA-155/SOCS-1 network

Downregulation of the Aβ deposits and phosphorylated Tau (p-Tau)

[50]

APPtg and TAUtg mice

MSK1, GSK3β

Repressing the expression of GSK3β

Regulating amyloid-beta production or TAU phosphorylation

[51]

hTau mice

N/A

mTOR, MAPK, Wnt, and T-cell receptor signaling pathways

Phosphorylating tau

[30]

DS-like neuronal deficits in Snx27 − / − mice

C/EBPβ

miR-155/C/EBPβ/SNX27 pathway

Inducing synaptic dysfunction

[60]

3xTg-AD mice, Aβ oligomers or Aβ fibrils treated N9 microglia cells or primary astrocyte cells

SOCS1

miR-155/SOCS1/IL-6 pathway

Enhancing the expression of pro inflammatory factors

[74]

LPS-stimulated murine primary microglia

SOCS1, HIF1α, CEBPβ

TLR signal, NF-κB/RelA and STAT1/STAT3 signaling pathways

Inducing the M1-skewing of microglia

[75]

Fibrillar Aβ1-42-treated primary microglia

N/A

Regulating the endolysosomal pathway

Reducing the ability of microglia to catabolize fAβ1-42

[76]

Intraperitoneal injection of LPS

SHIP-1

miR-155/SHIP-1/p-AKT axis

Downregulation the expression of inflammatory factors

[77]

A rat model of AD

N/A

Increasing the expression of IL-1β, IL-6 and TNF-α

Aggravating neuroinflammation

[79]

Mice lacking mineralocorticoid receptors in smooth muscle cells

Cav1.2, AgtR1

miR-155/Cav1.2/AgtR1 axis

Regulating vasoconstriction in the aging vasculature

[89]

A pregnant hypertension rat model

FOXO3a

miR-155/ FOXO3a

Regulating placental tissue morphology, blood pressure and serum creatine level 30,402,830

[92]

A rat hypertension model

P27

miR-155/P27

Regulating Vascular smooth muscle cell proliferation 30468491

[94]

Two-kidney-one-clip -induced renovascular endothelial dysfunction

eNOS

NF-κB/miR-155-5p/eNOS/NO/IκB

Improving vascular endothelial function

[93]

Atherosclerotic ApoE − / − mouse model

NoxA1

miR-155-NoxA1-p47phox complex signaling pathway

Promoting vascular smooth muscle cells proliferation and neointima formation

[104]

Mir155 − / − Ldlr − / − mice and Mir155 − / − Apoe − / − mice

MafB

miR-155/ MafB/IL-6

Limiting the progression of obesity and atherosclerosis

[99]

ApoE − / − mice

NLRP3

ERK1/2/NF-κB/NLRP3 pathway

Aggravating inflammation and promoting the development of atherosclerosis

[105]

ApoE − / − mice

SOCS1

SOCS1/STAT3/PDCD4 pathway

Regulating inflammation

[106]

Controlled cortical impact-induced experimental TBI

SOCS1

SOCS1 rather than SHIP-1 pathway

Promoting post-traumatic neuroinflammatory responses

[110]

Controlled cortical impact-induced experimental TBI

N/A

Promotes the type 1 IFN response

Regulating TBI pathophysiology

[111]

Controlled cortical impact-induced experimental TBI

PGC-1α

MiR-155/PGC-1α

Suppressing mitochondrial biogenesis

[112]

Distal middle cerebral artery occlusion (dMCAO) model

Rheb

Rheb/p-AKT/ZO-1 pathway

Destroying the integrity of BBB

[115]

Middle cerebral artery occlusion (MCAO) model

TLR4

TLR4/MyD88 pathway

Resulting in the development of cell damage

[116]

Middle cerebral artery occlusion/reperfusion (MCAO/R) model

DUSP14

NF-κB and MAPKs signaling pathways

Causing cell injury and inflammation

[117]

Middle cerebral artery occlusion (MCAO) model

Rheb

Rheb/mTOR pathway

Resulting in significant cerebral infarct volumes and cell apoptosis

[118]

Middle cerebral artery occlusion/reperfusion (MCAO/R) model

MafB

miR-155/ MafB

Improving the neurological function and inhibiting inflammation response

[119]

The blood samples of major depression disorder patients, human neural progenitor cells

SIRT1

MiR-155/ SIRT1 pathway

Mediating depression and anxiety-like behaviors

[124]

Chronic unpredictable mild stress-induced depression model

N/A

Wnt/β-catenin signaling pathway

Promoting the release of inflammatory factors and the apoptosis of hippocampal neurons

[129]

Chronic unpredictable mild stress-induced depression model

FGF2

NF-κB/miR-155/FGF2

Aggravating depression and anxiety-like behaviors

[130]

MicroRNA-155 knockout mouse model and glioma mouse model

FoxO3a

FoxO3a/Akt/Stat5 signaling pathway

Repressing the proliferative and invasive abilities of CD8 + T cells

[145]

Immunological diseases-related models

SOCS1, SHIP1, c-Fos, SIRT1, c-Maf, FOXO3 etc

SOCS1/Stat5, SHIP1/AKT, SIRT1Foxop3 signaling pathway

Regulating CD4 + T cells

[147]