Fig. 2
From: Pathogenesis of miR-155 on nonmodifiable and modifiable risk factors in Alzheimer’s disease
Pathogenesis of miR-155 in AD-related modifiable risk factors. Hypertension, stroke, TBI, dyslipidemia, and depression are common AD-related modifiable risk factors. miR-155 regulates hypertension by inducing AgtR1, Cav1.2, FOXO3a, or p27. miR-155 might be involved in cerebrovascular diseases, including stroke and TBI. Among that, miR-155 is involved in stroke by regulating TLR4/MYD88, NF-kB, MAPKs, or Rheb/mTOR pathways, but regulate TBI on the basis of reactive gliosis, IFN response. miR-155 is involved in dyslipidemia by regulating APOE, especially in atherosclerosis. miR-155 can aggravate depression via targeting SIRT1, FGF2 or inducing inflammation