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Table 4 Significant correlations between plasma total apoE and plasma lipids

From: Plasma apolipoprotein E levels, isoform composition, and dimer profile in relation to plasma lipids in racially diverse patients with Alzheimer’s disease and mild cognitive impairment

Race/ethnicity

Studied subjects

Sample number (n)

Plasma lipids (mmol/L)

APOE genotype unaccounted for

APOE genotype accounted for

Correlation (95% CI)

p-value

Correlation (95% CI)

p-value

Whole cohort

All

125

t-Ch.

r = 0.228

(0.055, 0.388)

0.010

r (122) = 0.280

(0.110, 0.434)

0.002

HDL

ρ = 0.187

(0.012, 0.351)

0.037

r (122) = 0.414

(0.258, 0.549)

0.002

Controls

53

t-Ch.

r = 0.368

(0.108, 0.581)

0.007

r (50) = 0.414

(0.162, 0.615)

0.002

LDL

r = 0.285

(0.016, 0.516)

0.038

r (50) = 0.313

(0.047, 0.538)

0.024

AD

24

HDL

r = 0.506

(0.129, 0.755)

0.012

r (21) = 0.555

(0.195, 0.783)

0.006

LDL/HDL

r =  − 0.460

(− 0.728, − 0.070)

0.024

r (21) =  − 0.454

(− 0.725, − 0.062)

0.029

B/AAs

All

58

t-Ch.

ρ = 0.352

(0.104, 0.559)

0.007

r (55) = 0.367

(0.121. 0.571)

0.005

LDL

ρ = 0.327

(0.076, 0.539)

0.012

r (55) = 0.341

(0.091, 0.550)

0.009

Controls

25

t-Ch.

r = 0.456

(0.074, 0.721)

0.022

r (22) = 0.526

(0.165, 0.763)

0.008

LDL

r = 0.414

(0.023, 0.695)

0.040

r (22) = 0.464

(0.084, 0.726)

0.022

AD

9

t-Ch.

r = 0.671

(0.012, 0.924)

0.048

r (6) = 0.584

(− 0.131, 0.899)

0.128

NHWs

All

67

HDL

ρ = 0.269

(0.031, 0.478)

0.027

r (64) = 0.263

(0.025, 0.473)

0.033

AD

15

LDL/HDL

r =  − 0.562

(− 0.834, − 0.070)

0.029

r (12) =  − 0.462

(− 0.788, 0.066)

0.097

  1. Correlation was assessed using Pearson’s (r) correlation test or Spearman’s (ρ) rank coefficient. Partial correlations are shown as r (degrees of freedom) and were obtained after accounting for APOE genotype
  2. CI Confidence intervals, B/AAs Black/African-Americans, NHWs Non-Hispanic whites, apoE Apolipoprotein E, t-Ch. Total cholesterol, LDL Low-density lipoprotein, HDL High-density lipoprotein