Fig. 7
Change of IgM autoantibodies against acrolein-Aß adducts in human serum. A The relative levels of IgM autoantibody recognizing acrolein-modified Aß1-16 and Aß17-28 peptides in each group. All the values were normalized with the mean of healthy control (HC). B The ratio of the responding IgM to acrolein adducts of each subject in each group. In the box plots, the dots represent the 5th and 95th percentiles. The error bars cover the 10th to 90th percentiles and the box covers the 25th to 75th percentiles. The solid and dashed lines within the box represent the median and mean values, respectively. The receiver operating characteristic curves were plotted with the area under curve values shown in brackets when the p value is < 0.001 between groups. Aß, amyloid beta; AD-M, Alzheimer’s disease with metabolic disturbance; AD-N, Alzheimer’s disease with normal metabolism; HC, healthy control; MetS, metabolic syndrome.* p < 0.05, **p < 0.01, ***p < 0.001