Fig. 2

Correlation of acrolein adducts with specific metabolites in human serum. A Levels of Aß, acrolein adducts, and total protein (TP) in human serum samples. All the values were normalized with the mean of control. In the box plots, the dots represent the 5th and 95th percentiles; the error bars cover the 10th to 90th percentiles and the box covers the 25th to 75th percentiles; the solid and dash lines within the box represent the median and mean values, respectively. B Correlation of acrolein adducts with Aß and TP. Serum Aß and TP values were plotted against the level of acrolein adducts in control and AD subjects, respectively. The solid and broken lines represent the linear regression of the values in control and AD subjects, respectively. Pearson product moment correlation coefficients (r) of acrolein adducts with Aß and TP were shown with p values. C. Correlation of acrolein adducts with the metabolites related to metabolic syndrome. Serum fasting glucose (Glc), triglycerides (TG), and HDL-C values of control or AD subjects were plotted against the level of acrolein adducts. The solid and broken lines represent the regression of the values in control and AD subjects, respectively. Pearson product moment correlation coefficients (r) of acrolein adducts with Glc, TG, and HDL-C were shown with p values. Aß, amyloid-beta; AD, Alzheimer’s disease; Ctrl, control; HDL-C, high-density lipoprotein-cholesterol; TG, triglycerides; TP, total protein.*** p < 0.001